溫州醫(yī)科大學檢驗醫(yī)學與生命科學學院2014年考研調(diào)劑信息

24考研復試面試模擬體驗包（1次）

2024考研復試特訓班[1V1材料修改+面試模擬+聽口糾音]

一、錄取要求：

1.本實驗室擬招收生物學或臨床檢驗診斷學專業(yè)碩士研究生6名；

2.總分數(shù)、單科須過國家A類分數(shù)線；

3.來自“985”、“211”等高校的優(yōu)秀考生，同等條件下優(yōu)先錄��；

4.通過國家英語六級的優(yōu)秀考生，同等條件下優(yōu)先調(diào)劑。

二、待遇

1.除學校提供的生活補貼外，導師根據(jù)學生表現(xiàn)每月提供額外的勞務補貼。

2.為研究生提供良好的生活條件，國家和本校通過設立獎學金、助學金、助學貸款、三助崗位、綠色通道等制度，建立多元獎助體系。目前已設的獎學金如下：

國家獎學金：20000元。

臺灣光華教育基金會設立的光華獎學金：我校是浙江省屬院校中唯一設立該獎學金的學校。

中國科學院毛江森院士在我校設立的毛江森獎學金和助學金:特等獎學金2萬元,獎學金5000元，助學金2000元。

生物藥械豪森藥業(yè)獎學金和助學金：特等獎5000元，一等獎2000元，二等獎1000元，三等獎500元。

康泉獎學金：特等獎5000元。

東甌獎學金、迪安獎學金等。

三、實驗室基本情況

本實驗室近20年來致力于線粒體分子遺傳學和母性遺傳病致病機制的研究,主要方向有耳聾遺傳、Leber遺傳性視神經(jīng)病變、原發(fā)性高血壓,tRNA堿基修飾機制及其在線粒體疾病發(fā)病中的作用等。課題組已在國內(nèi)外著名刊物上發(fā)表論文100多篇，SCI收錄論文80余篇，累計影響因子300余分。導師管敏鑫教授作為國際線粒體分子遺傳學和母性遺傳病領域知名專家，國際該領域領軍人物之一，目前主持及參與國家“973”計劃項目，十二五支撐項目，國家自然科學基金重點項目等。熱誠歡迎對線粒體生物醫(yī)學研究感興趣的研究生加入我們的研究團隊！

四、導師簡介：

管敏鑫教授:

（一）基本信息：

1962年生于浙江省樂清市

1979.9-1983.7杭州大學（現(xiàn)浙江大學）生物系本科

1983.8-1989.9浙江圖書館館員

1989.9-1993.7澳大利亞國立大學（ANU）生物化學與分子生物學博士研究生

1993.8-1996.7加州理工學院（Caltech）人類分子遺傳學ResearchFellow

1996.8-1999.7加州理工學院生物系SeniorResearchFellow

1999.8-2011.9辛辛那提大學兒童醫(yī)院醫(yī)學中心人類遺傳學助理教授、副教授、教授

2011.1-2013.11浙江大學生命科學學院院長

2011.1-至今浙江大學生命科學學院教授、博導

（二）學術(shù)兼職

溫州醫(yī)學院生命科學學院院長,教授(2004-2010)

中國人民解放軍總醫(yī)院/軍醫(yī)進修學院客座教授（2002-至今）

美國辛辛那提大學兒童醫(yī)院醫(yī)學中心客座教授(2011.10-至今)

浙江省高等學校特聘教授(2006-2009)

浙江省醫(yī)學遺傳學重點實驗室學術(shù)委員會主任（2005-至今）

第四屆亞洲線粒體研究與醫(yī)學學會（ASMRM）主席（2011-至今）

（三）獎勵榮譽

國家“千人計劃”入選者(2012)

浙江省特聘專家(2010)

國務院政府特殊津貼(2010)

浙江省有突出貢獻中青年專家（2009）

浙江省優(yōu)秀留學回國人員（2008）

首批浙江省衛(wèi)生高層次創(chuàng)新人才（2007）

浙江省高等學校特聘教授（2006年）

浙江省“新世紀151人才工程”第一層次培養(yǎng)人員（2006）

國家自然科學基金海外及港澳學者合作研究基金(2006)

（四）主持項目

1.國家重點基礎研究發(fā)展計劃（973計劃）:單基因遺傳性聾病的分子機制研究,2014.1-2018.12

2.國家自然科學基金重點項目：核修飾基因調(diào)控母系遺傳性耳聾發(fā)病機制及聽覺功能重建的策略研究,2014.1-2017.12

3.十二五支撐項目：Leber遺傳性視神經(jīng)病變的分子診斷和治療研究,2012.1-2015.12

（五）研究成果

2009年度《母系遺傳藥物性耳聾致病機制研究及干預》中華醫(yī)學科技獎,二等獎

2009年度《母系遺傳藥物性耳聾致病機制的研究》浙江省科學技術(shù)獎,一等獎

2008年度《聾病發(fā)生的分子機制與防控預警的系統(tǒng)研究》國家科技進步獎,二等獎

2007年度《Leber氏遺傳性視神經(jīng)萎縮遺傳性狀研究》，國家科技進步獎,二等獎

（六）代表性論文
耳聾遺傳
Guan, M.X., Fischel-Ghodsian,N. and Attardi,G. (1996) Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation.Hum. Mol. Genet. 5:963-972.
Guan, M.X.,Enriquez,J.A., Fischel-Ghodsian, N., Puranam, R., Lin, C.P., Marion, M.A. and Attardi,G. (1998) The Deafness-associated mtDNA 7445 mutation, which affects tRNAprecursor processing, has long-range effects on NADH dehydrogenase ND6 subunit gene expression.Mol. Cell. Biol.18:5868-5879.
Guan, M.X,Fischel-Ghodsian, N. and Attardi,G. (2000) A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity.Hum. Mol. Genet. 9: 1787-1793.
Guan, M.X.,Fischel-Ghodsian, N. and Attardi,G. (2001) Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation.Hum. Mol. Genet.10: 573-580.
Li, X., Fischel-Ghodsian,N., Schwartz, F., Yan, Q., Friedman,R.A. and*Guan,M.X.(2004) Biochemical characterization of the mitochondrial tRNAT7511C mutation associated with nonsyndromic deafness.Nucleic Acids Res.32: 867-877.
Zhao, H., Li, R., Wang, Q., Yan, Q., Deng, J.H., Han, D., Bai, Y., Young, W.Y. and*Guan, M.X. (2004) Maternally inherited aminoglycoside-induced and non-syndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family.Am. J. Hum. Genet.74:139-152.
Li, R., Greinwald, J.H., Yang, L., Choo, D.I., Wenstrup, R.J. and*Guan, M.X.(2004) Molecular analysis of mitochondrial 12S rRNA and tRNAgenes in pediatric subjects with nonsyndromic hearing loss.J. Med. Genet. 41:615-620.
Li, Z., Li, R., Chen, J., Liao, Z.,Zhu,Y., Qian,Y., Xiong,S., Heman-Ackah,S., Wu, J., Choo, D.I., and*Guan, M.-X.(2005)Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside induced and non-syndromic hearing loss.Hum. Genet.117:9-15.
Zhao, H., Young, W.Y., Yan, Q., Li, R., Cao, J., Wang, Q., Li, X., Peters, J.L., Han, D., and*Guan, M.X.(2005) Functional characterization of the mitochondrial 12S rRNA C1494T mutation associated with aminoglycoside-induced and nonsyndromic hearing loss.Nucleic Acid Res.33:1132-1139.
*Guan, M.X,Yan, Q., Li, X., Bykhovskaya, Y., J. Gallo-Teran, P. Hajek, N. Umeda, H. Zhao, G. Garrido, E. Mengesha, T.Suzuki, I.del Castillo, J.L. Peters, R. Li, Qian, Y., Wang, X., Ballana, E., M. Shohat, Lu, J., X. Estivill,K. Watanabe, & Fischel-Ghodsian, N. (2006) Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.Am. J. Hum. Genet.79:291-302.
Qian Y,*Guan MX.(2009) Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation.Antimicrob Agents Chemother. 53:4612-4618.
Guan, MX.(2011) Mitochondrial 12S rRNA Mutations associated with aminoglycoside ototoxicity.Mitochondrion11: 237-245.
Yan X, Wang X, Wang Z, Sun S, Chen G, He Y, Mo JQ, Li R, Jiang P, Lin Q, Sun M, Li W, Bai Y, Zhang J, Zhu Y, Lu J, Yan Q, Li H,Guan MX. (2011)Maternally transmitted late-onset non-syndromic deafness is associated with the novel heteroplasmic T12201C mutation in the mitochondrial tRNAgene. J Med Genet. 48:682-90.
Raimundo N, Song, L, Shutt TE, McKay SE, Cotney J,Guan MX, Gilliland TC, Hohuan, D, Santos-Sacchi S, Shadel GS. (2012) Mitochondrial Stress Engages E2F1Apoptotic Signaling to Cause Deafness. Cell. 148, 716-726.
Chen H, Zheng J, Xue L, Meng Y, Wang Y, Zheng B, Fang F, Shi S, Qiu Q, Jiang P, Lu Z, Mo JQ, Lu J,Guan MX. (2012)The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees.Eur J Hum Genet.20(6):607-12.
Zheng J, Ji Y, Guan MX (2012)Mitochondrial tRNA mutations associated with deafness.Mitochondrion. 2012 May;12(3):406-13.
Leber遺傳性視神經(jīng)病變

Qu,J., Li,R., Tong,Y., Zhou,X., Lu,F., Qian,Y., Hu,Y., Mo, J.Q., West, C.E.,*Guan, M.X.(2006) The novel A4435G mutation in the mitochondrial tRNAmay modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family.Invest. Ophth. Vis. Sci.47:475-83.

Qu, J., Zhou, X., Zhang, J., Zhao, F., Sun, Y.H., Yong, Y., Wei, Q.P., Cai, W., West, C.E. and*Guan, M.X. (2009) Extremely low penetrance of Leber’s hereditary optic neuropathy in eight Han Chinese families carrying the ND4 G11778A mutation.Ophthalmology16:558-564.

Qu J, Wang Y, Tong Y, Zhou X, Zhao F, Yang L, Zhang S, Zhang J, West CE,*Guan MX.(2010)Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.Invest Ophthalmol Vis Sci. 51:4906-4912.

Liu XL, Zhou T, Zhou J, Zhao F, Zhang J, Li C, Ji Y, Zhang Y, Wei QP,Sun YH, Yang L, Lin B, Yuan Y, Li Y, Qu J,*Guan MX.(2011) Leber’s hereditary optic neuropathy is associated with the novel T12338C mutation in mitochondrial ND5 gene in six Han Chinese families.Ophthalmology118:.978-985.

原發(fā)性高血壓

Liu, Y., Li, R., Li, Z., Wang, X., Yang, L., Wang, S.,Guan, M.X.(2009).The mitochondrial tRNA4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree.Hypertension.53:1083-1090.

Li, R., Liu, Y., Li, Z., Yang, L., Wang, S.,Guan, M.X. (2009) Failures in mitochondrial tRNAand tRNAmetabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese family.Hypertension54:329-337.

Wang SW,Li RH, Fettermann A, Li ZB, Qian YP, Liu YQ, Wang XJ, Zhou A, Mo JQ, Yang L, Jiang PP, Taschner A, Rossmanith W,andGuanMX.. (2011) Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAgene in a large Han Chinese family.Circ. Res.108:862-70.

Lu Z, Chen H, Meng Y, Wang Y, Xue L, Zhi S, Qiu Q, Yang L, Mo JQ,*Guan MX. (2011) The tRNA4435A>G mutation in the mitochondrial haplogroup G2a1 is responsible for maternally inherited hypertension in a Chinese pedigree.Eur J Hum Genet. 19(11):1181-6
Qiu Q, Li R, Jiang P, Xue L, Lu Y, Song Y, Han J, Lu Z, Zhi S, Mo JQ, Guan MX. (2012)Mitochondrial tRNA mutations are associated with maternally inherited hypertension in two Han Chinese pedigrees.Hum Mutat. 2012 May 1. doi: 10.1002/humu.22109. [Epub ahead of print]

線粒體tRNA堿基修飾機制

Li, X., Li,R., Lin,X. and*Guan,M.X.(2002) Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12S rRNA A1555G mutation.J. Biol. Chem.277:27256-27264.

Li, X.,*Guan,M.X.(2002) A human mitochondrial GTP binding protein related to tRNA modification may modulate the phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation.Mol. Cell. Biol.22:7701-7711.

Yan, Q., Li, X., Faye, G. and *Guan, M.X. (2005) Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15S rRNA.J. Biol. Chem. 280: 29151-29157.

Guan, M.X,Yan, Q., Li, X., Bykhovskaya, Y., J. Gallo-Teran, P. Hajek, N. Umeda, H. Zhao, G. Garrido, E. Mengesha, T.Suzuki, I.del Castillo, J.L. Peters, R. Li, Qian, Y., Wang, X., Ballana, E., M. Shohat, Lu, J., X. Estivill,K. Watanabe, & Fischel-Ghodsian, N. (2006) Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.Am. J. Hum. Genet.79:291-302.

Wang X, Yan Q,*Guan MX.(2010) Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNA, tRNA, and tRNAaltered mitochondrial biogenesis and respiration.J Mol Biol.395:1038-1048.

Li R,*Guan MX. (2010) Human mitochondrial leucyl-tRNA synthetase correctes mitochondrial dysfunctions due to the MELAS and diabetes associated tRNAA3243G mutation.Mol Cell Biol. 30:2147-54.

五、聯(lián)系方式

有意者，請聯(lián)系鄭老師，郵箱：148271673@qq.com

24考研復試面試模擬體驗包（1次）

2024考研復試特訓班[1V1材料修改+面試模擬+聽口糾音]

2024考研復試標準班【復試指導+中英文面試模擬+復試資料】